Software Competence Center Hagenberg (SCCH) - Austria

Supervisor: Julian Mattes

Student: Dmytro Kotsur

14 - Model validation - integrating shape change models and imaging

In order to verify how well the predictions of cellular surface motion correspond to the motion of real cells, in a first step, we will compare, on a statistical level, a number of parameters describing the motion produced by simulations with the same parameters calculated for real cells. In a second step we will initialise the model's parameters by data measured from a concrete real cell and then compare the predicted states with the measurements obtained for the same cell at later time points. Rather than only comparing predicted and real states, we plan to define a certain set of “free” parameters of the model which we will adjust by minimising the difference between the predicted state and real state for other parameters. This will result in the development of optimal control models for cell motility.