Workshop 2: Early start-up phase
3 weeks; target group: all ESRs and beneficiaries and partner organisations
This workshop will take place immediately after completing the recruitment phase:
Week 1 and 2:
Introduction to InCeM and setup of network structure (Isaac Newton Institute, Cambridge, UK)
Introduction to cutting-edge techniques for examining and analysing cell migration
(FZJ Jülich/Uniklinik RWTH Aachen)
Last update: 26.09.2018
Migrating primary keratinocyte with labelled cell adhesions. Based on a fine tuned regulation adhesion structures are continuously formed, modified and finally disassembled.
Primary keratinocytes apply traction forces upon migration. Using fluorescent fusion proteins (GFP-vinculin), adhesion structures can be visualized. Those sites are used by the cell for cell force transmission to the underlying substrate. In case those substrates are elastic, forces cause deformation fields that can be visualized using marker particles.
A typical example of the application of the evolving surface finite element method when solving partial differential equations of reaction-diffusion type on an evolving closed surface representing an evolving tumour.
A typical example of the application of the evolving surface finite element method when solving partial differential equations of reaction-diffusion type on an evolving open surface.
Time-lapse recordings of HK18-YFP fluorescence (left) of a migrating EK18-1 cell displaying multiple emerging KFPs in the proceeding lamellipodium. (Kölsch et al., 2010)
Induction of cell border dynamics through UV-light induced activation of pa-rac.
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 642866.