The European network

for cell migration studies

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 642866.

incem@rwth-aachen.de

Advanced cell migration assays (P1)

15 - Integration of forces and life times

A typical example of the application of the evolving surface finite element method when solving partial differential equations of reaction-diffusion type on an evolving open surface. The evolving surface finite element is a powerful numerical method for providing numerical solutions of systems of partial differential equations routinely encounter in cell biology where for example, the cell surface is continuously evolving. Here we exhibit patterns formed during cell-surface evolution.

We propose to develop integrative mathematical and computational models describing the biochemical and biomechanical properties of single cell migration at different scales and locations. Our aim is to couple life time models, membrane shape forces, protein-driven cell motion, and cell tracking and imaging. We will link models within the bulk of the cell surface (interior of the cell) to models (gradient sensing, chemotactic, etc.) posed only on the cell surface. The computational tools will then be used to validate experimental observations, inform experimental manipulations as well as to suggest further model refinement where necessary.

Real-time tracking of keratinocyte migration and analysis of cell membrane shape changes (P10)

Speckle analysis of actin and keratin filament dynamics (P11)

Life time models (P12)

Shaping membranes and actin fibres by forces (P13)

Model validation - integrating shape change models and imaging (P14)

Integration of forces and life times (P15)

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Last update: 18.04.2016