The European network

for cell migration studies

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 642866.

1  -  Advanced cell migration assays

incem@rwth-aachen.de

With existing migration assays the acquisition of cell migration data can normally only be observed in relation to one physical parameter such as a chemical gradient or surface topology. Relevant information for the understanding of cell behaviour, however, requires observations to be performed in the presence of several precisely adjusted parameters. In the project we aim to establish (i) new cell migration assays in which movement of cells can be correlated to several fixed parameters at the same time, (ii) a microscope slide that allows investigating cell migration in a chemical gradient, and (iii) track and analyse cell shapes to obtain additional information on overall cell motility as well as to calculate the forces of the cells applied to a matrix of defined stiffness.

Real-time tracking of keratinocyte migration and analysis of cell membrane shape changes (P10)

Image analysis of integrated cytoskeletal network dynamics (P11)

Coupling bulk-surface models for cell migration (P12)

Shaping membranes and actin fibres by forces (P13)

Integrating shape change models and imaging – inverse problem solving and model validation (P14)

Understanding spatio-temporal dynamics of the cytosol network during cell migration  (P15)

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Last update: 04.04.2017