The European network

for cell migration studies

InCeM's research

To develop comprehensive  cell  migration models,  InCeM will focus on the main structural (actin,  keratin, adhesions) and regulatory (GTPases and kinases) factors in force generation. Technically challenging simultaneous monitoring of multiple factors will be conducted at cellular and subcellular resolution for subsequent mechanistic and predictive mathematical modelling.

Advanced cell migration assays (P1)

Chemotaxis and 2D/3D migration (P2)

Analysis of keratin dynamics during migration (P3)

Impact of keratin network regulation on migrating cells (P4)

Correlation analyses of migration structure components and front-rear interplay  (P5)

Life cycle analysis of actin, focal adhesions and force measurements (P6)

Monitoring of cancer cell migration in living animals  (P7)

Principles of the filopodia structure, dynamics and mechanics (P8)

Mechanisms of downstream signalling from the Rho GTPase network to

cell morphogenesis and cell motility  (P9)

Real-time tracking of keratinocyte migration and analysis of cell membrane shape changes (P10)

Image analysis of integrated cytoskeletal network dynamics (P11)

Coupling bulk-surface models for cell migration (P12)

Shaping membranes and actin fibres by forces (P13)

Integrating shape change models and imaging – inverse problem solving and model validation (P14)

Understanding spatio-temporal dynamics of the cytosol network during cell migration (P15)

Last update: 26.09.2018

incem@rwth-aachen.de

NEWS

November 2018

InCeM

September 5th, 2018                                ­

University of Sussex

July 26th, 2018                                ­

InCeM

February 22-23, 2018 in Vienna

GALLERY

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 642866.